When I’m on Tobramycin inhaled for a lung infection, I often have difficulty sleeping, feel constantly tired and ill with migraines, and also feel mildly depressed. The mild depression lingers beyond the course of antibiotics, but is ameliorated slightly with time away from the course.
Here are some things that I’ve found, surprisingly, help me a lot with my mood! These help me even when I’m not on the antibiotics (1+ years later)! I assume it is because of the post-antibiotic effect of aminoglycosides. If you, or someone with CF, has irritability or depression and has been on tobramycin or gentamicin, you might want to try a few of these tricks! The first 3 listed items are the most potent for me!!
Aspirin 41mg (half of a baby aspirin) and 1.25mg of pure melatonin (no l-theanine, or other additives) I take this when I wake up in the middle of the night or too early in the morning (I’ve taken the aspirin every day for 2 months, and the positive effects seem to be compounding…. Starting to feel better in general than I have in 1+ years)
DL Methionine 400mg, 2 times a day with food while following a high protein, Low FODMAP diet. This really helps me a lot. I’m doing this in conjunction with the above, and it seems to be helping quite a lot.
Vitamin D3 supplement (2000iu) This one has had a remarkable effect on my mood for just being a vitamin! I’ve tracked my self-confidence with and without vitamin d, and I found I’m much more self confident with the supplement!it could be psychological… But who cares if it works! 🙂
Here are some other things that definitely help:
200mg NAC I don’t think that this has had a huge impact on making me feel better, but definitely does something.
Copper supplement (2mg), vitamin e 100iu, vitamin K2 100mg
Here are some studies on the interactions between melatonin, aspirin, D methionine, NAC, Vitamin E, and aminoglycosides.
Aspirin and Vitamin E: https://www.hindawi.com/journals/ijoto/2011/937861/
D Methionine: https://www.ncbi.nlm.nih.gov/pubmed/26166286
Keep fightin CFrs!!